Home PI3K/Akt/mTOR Antioxidant chemical Maltol For research use only.

Maltol

Synonyms: Larixinic acid, Palatone, Veltol

Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.

Maltol Chemical Structure

Maltol Chemical Structure

CAS No. 118-71-8

Purity & Quality Control

Batch: S494001 DMSO]25 mg/mL]false]]]false]]]false Purity: 98%
98

Maltol Related Products

Biological Activity

Description Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.
In vitro
In vitro

Maltol can effectively protect nerve cells against oxidative damage caused by ROS in order to maintain normal physiological functions of cells and inhibit diabetes-induced oxidative stress and irreversible kidney damage[1].
In Vivo
In vivo

For hepatoprotective activity in vivo, pretreatment with maltol (12.5, 25 and 50 mg/kg; 15 days) drastically prevents the elevated activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and triglyceride (TG) in serum and the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) in liver tissue. Meanwhile, the levels of hepatic antioxidant, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) are elevated by maltol pretreatment, compared to the alcohol group. Maltol pretreatment significantly inhibits alcohol-induced hepatocyte apoptosis and fatty degeneration. It is effective in the prevention of alcohol-induced hepatic damage in mice[1]. Also, maltol is suggested to be a functional agent to prevent the oxidative damage in the brain of mice[2].
Animal Research Animal Models Male ICR mice
Dosages 12.5, 25 and 50 mg/kg
Administration by gastric intubation
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05177484 Recruiting
Cancer Colon
The Royal Wolverhampton Hospitals NHS Trust|Norgine
 May 30 2022 Phase 3
NCT05126901 Recruiting
Anemia|Iron-deficiency
Shield Therapeutics
 October 4 2021 Phase 3
NCT04626414 Unknown status
Anemia Iron Deficiency
Shield Therapeutics
 September 28 2020 Phase 1
NCT03774615 Terminated
Heart Failure Left Sided|Anemia Iron Deficiency
Hannover Medical School|Shields Shields and Associates
 March 18 2019 Phase 4
NCT03181451 Completed
Iron Deficiency Anaemia in Children|Iron-Deficiency
Shield Therapeutics|Medpace Inc.
 March 14 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 126.11 Formula

C6H6O3
CAS No. 118-71-8 SDF --
Smiles CC1=C(C(=O)C=CO1)O
Storage (From the date of receipt) 3 years -20°C powder (seal)

In vitro
Batch:

DMSO : 25 mg/mL ( (198.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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