Home Metabolism PAI-1 inhibitor - ERK inhibitor - JNK inhibitor - Potassium Channel inhibitor - Calcium Channel inhibitor Loureirin B For research use only.

Loureirin B

Synonyms: LB, LrB

Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.

Loureirin B Chemical Structure

Loureirin B Chemical Structure

CAS No. 119425-90-0

Purity & Quality Control

Batch: S324201 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.54%
99.54

Loureirin B Related Products

Biological Activity

Description Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.
Targets
p-ERK [2] p-JNK [2] Calcium Channel [3] Potassium Channel [3] PAI-1 [1]
(Cell-free assay)
26.10 μM
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Chemical Information & Solubility

Molecular Weight 316.35 Formula

C18H20O5
CAS No. 119425-90-0 SDF --
Smiles COC1=CC(=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC)OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 100 mg/mL ( (316.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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