Home Neuronal Signaling BACE inhibitor - AChR inhibitor - BChE inhibitor Loganin For research use only.

Loganin

Synonyms: Loganoside

Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

Loganin Chemical Structure

Loganin Chemical Structure

CAS No. 18524-94-2

Purity & Quality Control

Batch: S383501 DMSO]78 mg/mL]false]]]false]]]false Purity: 99.94%
99.94

Loganin Related Products

Signaling Pathway

BACE Signaling Pathways

BACE Signaling Pathway

Biological Activity

Description Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.
Targets
AChE [1]
(Cell-free assay)		 BChE [1]
(Cell-free assay)		 BACE1 [1]
(Cell-free assay)
3.95 μM 33.02 μM 47.97 μM
In vitro
In vitro In SMN-deficient NSC34 cells, loganin increases cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3, p-CREB, BDNF and Bcl-2. Loganin attenuates H2O2-induced neuronal damage via suppressing MAPKs signals in SH-SY5Y cells[2]. Loganin may directly promote the differentiation and inhibit the apoptosis of MC3T3-E1 cells and indirectly reduce bone resorption. Loganin could directly enhance the function of osteoblasts and elevate their survival rate, indirectly inhibit the function of osteoclastd and reduce the number of osteoclastd via RANKL from osteoblastd[3].
Cell Research Cell lines NSC34 cells
Concentrations 0.01, 0.1, 1, 10 μM
Incubation Time 48 h
Method --
In Vivo
In vivo Loganin provides benefits to SMA (pinal muscular atrophy) therapeutics via improving SMN (survival motor neuron) restoration, muscle strength and body weight. In type 2 diabetes mice, loganin not only lowers blood glucose but also attenuates hyperglycemia-induced inflammation, oxidative stress and apoptosis. Loganin improves spatial memory in streptozotocin-induced diabetic rats and exhibits antiamnesic activity in scopolamine-treated mice via acetylcholinesterase inhibition[2].
Animal Research Animal Models Transgenic mice expressing SMA-like phenotypes
Dosages 15 mg/kg/day
Administration s.c.

Chemical Information & Solubility

Molecular Weight 390.38 Formula

C17H26O10
CAS No. 18524-94-2 SDF Download Loganin SDF
Smiles CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 78 mg/mL ( (199.8 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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