Lixivaptan (VPA-985)

Synonyms: CRTX 080, WAY VPA 985

Lixivaptan (VPA-985, CRTX 080, WAY VPA 985) is an oral, non-peptide, selective V2 receptor vasopressin antagonist with IC50s of 1.2 nM and 2.3 nM for human V2 receptor and rat V2 receptor, respectively.

Lixivaptan (VPA-985) Chemical Structure

Lixivaptan (VPA-985) Chemical Structure

CAS No. 168079-32-1

Purity & Quality Control

Batch: S281501 DMSO]95 mg/mL]false]Ethanol]7 mg/mL]false]Water]Insoluble]false Purity: 99.48%
99.48

Lixivaptan (VPA-985) Related Products

Biological Activity

Description Lixivaptan (VPA-985, CRTX 080, WAY VPA 985) is an oral, non-peptide, selective V2 receptor vasopressin antagonist with IC50s of 1.2 nM and 2.3 nM for human V2 receptor and rat V2 receptor, respectively.
Targets
human V2 receptor [1] rat V2 receptor [1]
1.2 nM 2.3 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05208866 Terminated
Polycystic Kidney Disease Adult
Palladio Biosciences|Centessa Pharmaceuticals plc
February 10 2022 Phase 3
NCT04064346 Terminated
Autosomal Dominant Polycystic Kidney|ADPKD
Palladio Biosciences|Centessa Pharmaceuticals plc
October 28 2021 Phase 3
NCT04152837 Terminated
Polycystic Kidney Disease Adult|ADPKD
Palladio Biosciences|Centessa Pharmaceuticals plc
September 2 2020 Phase 3
NCT03487913 Completed
Autosomal Dominant Polycystic Kidney Disease
Palladio Biosciences
September 14 2018 Phase 2
NCT01055912 Completed
Congestive Heart Failure
CardioKine Inc.|Cardiokine Biopharma LLC
January 2010 Phase 2
NCT01056848 Completed
Hyponatremia With Normal Extracellular Fluid Volume|Hyponatremia With Excess Extracellular Fluid Volume
CardioKine Inc.|Cardiokine Biopharma LLC|Biogen
January 2010 --

Chemical Information & Solubility

Molecular Weight 473.93 Formula

C27H21ClFN3O2

CAS No. 168079-32-1 SDF --
Smiles CC1=C(C=C(F)C=C1)C(=O)NC2=CC(=C(C=C2)C(=O)N3CC4=CC=C[N]4CC5=CC=CC=C35)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 95 mg/mL ( (200.45 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 7 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Lixivaptan (VPA-985) | Lixivaptan (VPA-985) supplier | purchase Lixivaptan (VPA-985) | Lixivaptan (VPA-985) cost | Lixivaptan (VPA-985) manufacturer | order Lixivaptan (VPA-985) | Lixivaptan (VPA-985) distributor