Home Neuronal Signaling Histamine Receptor inhibitor Levodropropizine For research use only.

Levodropropizine

Synonyms: (S)-(-)-Dropropizine,DF-526

Levodropropizine((S)-(-)-Dropropizine,DF-526) possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.

Levodropropizine Chemical Structure

Levodropropizine Chemical Structure

CAS No. 99291-25-5

Purity & Quality Control

Batch: S413101 DMSO]47 mg/mL]false]Ethanol]47 mg/mL]false]Water]15 mg/mL]false Purity: 99.98%
99.98

Levodropropizine Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Levodropropizine((S)-(-)-Dropropizine,DF-526) possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.
Features Demonstrates a better tolerability index than the Racemate.
Targets
Histamine receptor [1]
In vitro
In vitro

Levodropropizine has affinity for H1-histaminic and alpha-adrenergic receptors. [1]
In Vivo
In vivo

Levodropropizine has weaker central sedative effects than the racemate and it does not induce physical dependence in rats. [1] Levodropropizine (15 mg/kg, i.v.) reduces both the duration of apnoea and the response of the C-fibre to phenylbiguanide. The LVDP-induced inhibition of the C-fibre response to PBG is on average 50% in pulmonary and 25% in non-pulmonary fibres. [2] Levodropropizine is shown to have good antitussive activity in anaesthetized guinea-pigs and rabbits. Levodropropizine (i.v.) is 1/10 to 1/20 as active as codeine and comparable to dropropizine on mechanically and electrically induced coughing in rabbits and guinea-pigs. Levodropropizine (orally) is comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols. [3] Levodropropizine (40 μg/50 μL i.c.v.) does not prevent electrically-induced cough, while Codeine (5 μg/50 μl i.c.v.) markedly prevents coughing in guinea-pigs. Levodropropizine has a peripheral site of action which is related to sensory neuropeptides. [4] Levodropropizine (10 mg/kg, 50 mg/kg and 200 mg/kg) reduces in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin in the rat trachea. Levodropropizine (200 mg/kg) inhibits also substance P-evoked extravasation, whereas it does not affect the extravasation evoked by platelet activating factor. [5]

Chemical Information & Solubility

Molecular Weight 236.31 Formula

C13H20N2O2
CAS No. 99291-25-5 SDF Download Levodropropizine SDF
Smiles C1CN(CCN1CC(CO)O)C2=CC=CC=C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 47 mg/mL ( (198.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 47 mg/mL

Water : 15 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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