Home Microbiology HCV inhibitor Ledipasvir acetone For research use only.

Ledipasvir acetone

Synonyms: GS-5885 acetone

Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively.

Ledipasvir acetone Chemical Structure

Ledipasvir acetone Chemical Structure

CAS No. 1441674-54-9

Purity & Quality Control

Batch: S443401 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.76%
99.76

Ledipasvir acetone Related Products

Biological Activity

Description Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively.
Targets
GT1b replicon [1]
(Cell-free assay)		 GT1a replicon [1]
(Cell-free assay)
4 pM(EC50) 31 pM(EC50)
In vitro
In vitro

Ledipasvir acetone induces HCV clearance, inhibits STAT3 protein levels and restores HNF4A expression.[1]
Cell Research Cell lines highly permissive transformed liver Huh-7.5 cell line
Concentrations --
Incubation Time 9 days
Method

--

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03903185 Completed
Hepatitis C Chronic|Hematologic Malignancy
Ain Shams University|Cairo University
 March 1 2019 Phase 1|Phase 2
NCT03639207 Withdrawn
Hepatitis C Virus
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 June 15 2018 --
NCT05091008 Completed
Hepatitis C Chronic
Mansoura University Children Hospital
 March 1 2018 Phase 2

Chemical Information & Solubility

Molecular Weight 947.08 Formula

C52H60F2N8O7
CAS No. 1441674-54-9 SDF --
Smiles COC(=O)NC(C(C)C)C(=O)N1CC2(CC2)CC1C3=NC=C([NH]3)C4=CC5=C(C=C4)C6=C(C=C(C=C6)C7=CC8=C(C=C7)N=C([NH]8)C9C%10CCC(C%10)N9C(=O)C(NC(=O)OC)C(C)C)C5(F)F.CC(C)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (105.58 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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