Home Neuronal Signaling Histamine Receptor antagonist Lafutidine For research use only.

Lafutidine

Synonyms: FRG-8813

Lafutidine (FRG-8813), a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

Lafutidine Chemical Structure

Lafutidine Chemical Structure

CAS No. 118288-08-7

Purity & Quality Control

Batch: S206501 DMSO]86 mg/mL]false]Ethanol]13 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Lafutidine Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Lafutidine (FRG-8813), a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.
Targets
Histamine H2 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02759224 Completed
Gastric Ulcer
Boryung Pharmaceutical Co. Ltd
 April 15 2016 Phase 1
NCT02581696 Completed
Peptic Ulcer
Boryung Pharmaceutical Co. Ltd|The Catholic University of Korea
 August 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 431.55 Formula

C22H29N3O4S
CAS No. 118288-08-7 SDF Download Lafutidine SDF
Smiles C1CCN(CC1)CC2=CC(=NC=C2)OCC=CCNC(=O)CS(=O)CC3=CC=CO3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 86 mg/mL ( (199.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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