Home Cell Cycle Ras inhibitor Opnurasib (JDQ-443) For research use only.

Opnurasib (JDQ-443)

Synonyms: NVP-JDQ443

Opnurasib (JDQ-443,NVP-JDQ443) , a potent and selective, orally bioavailable covalent inhibitor of GDP-bound KRASG12C with an IC50 of 0.012 µM for inhibition of c-Raf recruitment.

Opnurasib (JDQ-443) Chemical Structure

Opnurasib (JDQ-443) Chemical Structure

CAS No. 2653994-08-0

Purity & Quality Control

Opnurasib (JDQ-443) Related Products

Signaling Pathway

Ras Signaling Pathways

Ras Signaling Pathway

Biological Activity

Description Opnurasib (JDQ-443,NVP-JDQ443) , a potent and selective, orally bioavailable covalent inhibitor of GDP-bound KRASG12C with an IC50 of 0.012 µM for inhibition of c-Raf recruitment.
Targets
KRAS(G12C) [1]
0.012 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05445843 Recruiting
Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
Novartis Pharmaceuticals|Novartis
 December 6 2022 Phase 2
NCT05132075 Recruiting
Non-Small Cell Lung Cancer
Novartis Pharmaceuticals|Novartis
 June 15 2022 Phase 3
NCT05329623 Recruiting
Small Cell Lung Carcinoma
Novartis Pharmaceuticals|Novartis
 May 3 2022 Phase 1
NCT04699188 Recruiting
KRAS G12C Mutant Solid Tumors|Carcinoma Non-Small-Cell Lung|Carcinoma Colorectal|Cancer of Lung|Cancer of the Lung|Lung Cancer|Neoplasms Lung|Neoplasms Pulmonary|Pulmonary Cancer|Pulmonary Neoplasms
Novartis Pharmaceuticals|Novartis
 February 24 2021 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 526.03 Formula

C29H28CIN7O
CAS No. 2653994-08-0 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (190.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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