Home Protein Tyrosine Kinase ALK inhibitor Itacnosertib (TP-0184) For research use only.

Itacnosertib (TP-0184)

Synonyms: TP-0184

Itacnosertib (TP-0184) is a small-molecule inhibitor of the BMP type 1 receptor ALK2 (also known as ACVR1). Itacnosertib reduces hepcidin induction and elevated serum iron levels in turpentine and lung cancer mouse models of ACD.

Itacnosertib (TP-0184) Chemical Structure

Itacnosertib (TP-0184) Chemical Structure

CAS No. 1628870-27-8

Purity & Quality Control

Batch: E173201 DMSO]15 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.23%
99.23

Itacnosertib (TP-0184) Related Products

Signaling Pathway

ALK Signaling Pathways

ALK Signaling Pathway

Biological Activity

Description Itacnosertib (TP-0184) is a small-molecule inhibitor of the BMP type 1 receptor ALK2 (also known as ACVR1). Itacnosertib reduces hepcidin induction and elevated serum iron levels in turpentine and lung cancer mouse models of ACD.
Targets
ALK 2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04623996 Terminated
Anemia in Myelodysplastic Syndromes
Sumitomo Pharma America Inc.
 December 28 2020 Phase 1|Phase 2
NCT03429218 Completed
Advanced Solid Tumors
Sumitomo Pharma America Inc.
 July 10 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 468.55 Formula

C26H28N8O
CAS No. 1628870-27-8 SDF Download Itacnosertib (TP-0184) SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 15 mg/mL ( (32.01 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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