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Istiratumab (Anti-HER3 & IGF-1R)
Synonyms: MM-141
Istiratumab is a fully human tetravalent bispecific antibody that binds to and co-inhibits IGF-1R and the epidermal growth factor family of receptor tyrosine kinases B3 (ErbB3), with potential anti-tumor activity. MW: 199.64 KD.
Purity & Quality Control
Choose Selective HER2 Inhibitors
| Name | Citation | HER2 | Others |
|---|---|---|---|
| Canertinib (CI-1033) | 48 | EGFR | |
| CP-724714 | 108 | ||
| Sapitinib (AZD8931) | 48 | ErbB3,EGFR | |
| CUDC-101 | 22 | EGFR,HDAC,HDAC1 | |
| Mubritinib (TAK 165) | 39 | ||
| AEE788 (NVP-AEE788) | 13 | EGFR,c-Abl,FLT1 | |
| AC480 (BMS-599626) | 10 | HER1,HER4 | |
| TAK-285 | 4 | EGFR/HER1,HER4,MEK1 | |
| Tyrphostin AG 879 | 3 | Trk | |
| Tuxobertinib (BDTX-189) | 2 | EGFR,RIPK2,BLK | |
| Epertinib hydrochloride | 0 | EGFR,HER4 | |
| TAS0728 | 1 | ||
| Tyrphostin AG-528 | 0 | EGFR | |
| SU5204 | 1 | VEGFR-2 | |
| Pyrotinib dimaleate | 4 | EGFR | |
| Poziotinib | 34 | HER1,HER4 | |
| HER2-Inhibitor-1 | |||
| Zongertinib | EGFR-Ex20ins | ||
| Nordihydroguaiaretic acid (NDGA) | p300,IGF-1R,lipoxygenase | ||
| EGCG ((-)-Epigallocatechin Gallate) | FASN,EGFR,DNMT |
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.
Biological Activity
| Description | Istiratumab is a fully human tetravalent bispecific antibody that binds to and co-inhibits IGF-1R and the epidermal growth factor family of receptor tyrosine kinases B3 (ErbB3), with potential anti-tumor activity. MW: 199.64 KD. |
|---|
Product Details
| CAS No. | 1509928-04-4 |
|---|---|
| Source | CHO |
| Storage (From the date of receipt) |
-80℃ |
Comparison of Clones for
*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)
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