Home Protein Tyrosine Kinase IGF-1R modulator Insulin Degludec For research use only.

Insulin Degludec

Insulin degludec is an acylated basal insulin with a unique mechanism of protracted absorption involving the formation of a depot of soluble multihexamer chains after subcutaneous injection, shows a very long duration of action, with a half-life exceeding 25 h in PK/PD studies.

Insulin Degludec Chemical Structure

Insulin Degludec Chemical Structure

CAS No. 844439-96-9

Purity & Quality Control

Insulin Degludec Related Products

Signaling Pathway

IGF-1R Signaling Pathways

IGF-1R Signaling Pathway

Biological Activity

Description Insulin degludec is an acylated basal insulin with a unique mechanism of protracted absorption involving the formation of a depot of soluble multihexamer chains after subcutaneous injection, shows a very long duration of action, with a half-life exceeding 25 h in PK/PD studies.
Targets
IGF-1R [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06199505 Enrolling by invitation
Type 2 Diabetes
Gan and Lee Pharmaceuticals USA
 November 27 2023 Phase 2
NCT06202079 Recruiting
Diabetes Mellitus Type 2
Gan and Lee Pharmaceuticals USA
 August 29 2023 Phase 2
NCT04664764 Unknown status
Type 1 Diabetes Mellitus With Hypoglycemia|type1diabetes
Ain Shams University
 February 21 2019 Phase 4
NCT03736785 Completed
Type 2 Diabetes Mellitus
Eli Lilly and Company
 November 15 2018 Phase 2
NCT03674866 Completed
Diabetes Mellitus Type 1|Diabetes Mellitus Type 2
Novo Nordisk A/S
 October 29 2018 --
NCT03349840 Terminated
Type2 Diabetes
Weill Cornell Medical College in Qatar|Novo Nordisk A/S
 January 7 2018 Phase 4

Chemical Information & Solubility

Molecular Weight 6103.97204 Formula

C274H411N65O81S6
CAS No. 844439-96-9 SDF --
Smiles CCC(C)C(NC(=O)CN)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC1CSSCC2NC(=O)C(NC(=O)C(CO)NC(=O)C(NC(=O)C(CSSCC(NC(=O)C(CC(C)C)NC(=O)C(CC3=C[NH]C=N3)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC4=CC=CC=C4)C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC5=C[NH]C=N5)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CSSCC(NC(=O)C(CC7=CC=C(O)C=C7)NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(CC8=CC=C(O)C=C8)NC(=O)C(CC(C)C)NC(=O)C(CO)NC2=O)C(=O)NC(CC(N)=O)C(O)=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC9=CC=CC=C9)C(=O)NC(CC%10=CC=CC=C%10)C(=O)NC(CC%11=CC=C(O)C=C%11)C(=O)NC(C(C)O)C(=O)N%12CCCC%12C(=O)NC(CCCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC1=O)C(C)O)C(C)CC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (16.38 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Insulin Degludec | Insulin Degludec ic50 | Insulin Degludec price | Insulin Degludec cost | Insulin Degludec solubility dmso | Insulin Degludec purchase | Insulin Degludec manufacturer | Insulin Degludec research buy | Insulin Degludec order | Insulin Degludec mouse | Insulin Degludec chemical structure | Insulin Degludec mw | Insulin Degludec molecular weight | Insulin Degludec datasheet | Insulin Degludec supplier | Insulin Degludec in vitro | Insulin Degludec cell line | Insulin Degludec concentration | Insulin Degludec nmr