Home Angiogenesis HIF inhibitor IDF-11774 For research use only.

IDF-11774

IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.

IDF-11774 Chemical Structure

IDF-11774 Chemical Structure

CAS No. 1429054-28-3

Purity & Quality Control

Batch: S877101 DMSO]15 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.05%
99.05

IDF-11774 Related Products

Signaling Pathway

HIF Signaling Pathways

HIF Signaling Pathway

Biological Activity

Description IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
Targets
HIF-1 [1]
In vitro
In vitro

IDF-11774 inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells under hypoxic conditions. The treatment of IDF-11774 suppresses angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduces glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreases the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells. Therefore, IDF-11774 reduces cancer cell growth through the regulation of cancer glycolytic metabolism and energy production[1].
Cell Research Cell lines HCT116 cells
Concentrations 5, 10, 20 μM
Incubation Time 18 h
Method

--
In Vivo
In vivo

IDF-11774 exhibited substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations, which often occur in malignant cancers[1].
Animal Research Animal Models Balb/c nude mice bearing tumors (100 mm3) formed from HCT116 cells (1 × 107) expressing HRE-luciferase by subcutaneous injection
Dosages 50 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 368.51 Formula

C23H32N2O2
CAS No. 1429054-28-3 SDF --
Smiles CN1CCN(CC1)C(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 15 mg/mL ( (40.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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