Home Angiogenesis Syk inhibitor - JAK inhibitor Gusacitinib (ASN-002) For research use only.

Gusacitinib (ASN-002)

Gusacitinib (ASN-002) is a novel and potent dual inhibitor of spleen tyrosine kinase (SYK) and Janus kinases (JAK) with IC50 values of 5-46 nM in biochemical assays.

Gusacitinib (ASN-002) Chemical Structure

Gusacitinib (ASN-002) Chemical Structure

CAS No. 1425381-60-7

Purity & Quality Control

Gusacitinib (ASN-002) Related Products

Signaling Pathway

Syk Signaling Pathways

Syk Signaling Pathway

Biological Activity

Description Gusacitinib (ASN-002) is a novel and potent dual inhibitor of spleen tyrosine kinase (SYK) and Janus kinases (JAK) with IC50 values of 5-46 nM in biochemical assays.
Targets
SYK [1] JAK [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06238531 Not yet recruiting
Systemic Lupus Erythematosus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Phase 1
NCT04416516 Completed
Basal Cell Carcinoma|Basal Cell Nevus Syndrome
Ascend Biopharmaceuticals Ltd
 July 16 2020 Phase 2
NCT03641573 Completed
Healthy Volunteer
Asana BioSciences
 October 11 2018 Phase 1
NCT03208296 Suspended
Basal Cell Carcinoma in Basal Cell Nevus Syndrome
Ascend Biopharmaceuticals Ltd
 December 1 2017 Phase 1|Phase 2
NCT03139981 Completed
Dermatitis Atopic|Dermatitis Eczema|Dermatitis Eczematous
Asana BioSciences
 April 12 2017 Phase 1
NCT02853643 Completed
Healthy Volunteers
Asana BioSciences
 July 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 460.53 Formula

C24H28N8O2
CAS No. 1425381-60-7 SDF --
Smiles C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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