Home Proteases PAD inhibitor GSK199 For research use only.

GSK199

GSK199 is a reversible, specific inhibitor of peptidyl arginine deiminase 4 (PAD4), with an IC50 of 200 nM without calcium. It is involved in histone citrullination and neutrophil extracellular trap formation, making it useful for studying autoimmune, cardiovascular, and oncological diseases.

GSK199 Chemical Structure

GSK199 Chemical Structure

CAS No. 1549811-53-1

Purity & Quality Control

Batch: S780201 DMSO]94 mg/mL]false]Water]94 mg/mL]false]Ethanol]31 mg/mL]false Purity: 97.06%
97.06

GSK199 Related Products

Biological Activity

Description GSK199 is a reversible, specific inhibitor of peptidyl arginine deiminase 4 (PAD4), with an IC50 of 200 nM without calcium. It is involved in histone citrullination and neutrophil extracellular trap formation, making it useful for studying autoimmune, cardiovascular, and oncological diseases.

Chemical Information & Solubility

Molecular Weight 468.98 Formula

C24H28N6O2.ClH
CAS No. 1549811-53-1 SDF Download GSK199 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 94 mg/mL ( (200.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 94 mg/mL

Ethanol : 31 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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