Home Proteases DPP inhibitor Gemigliptin For research use only.

Gemigliptin

Synonyms: Zemiglo, LC15-0444

Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.

Gemigliptin Chemical Structure

Gemigliptin Chemical Structure

CAS No. 911637-19-9

Purity & Quality Control

Batch: E012201 DMSO]98 mg/mL]false]Water]12 mg/mL]false]Ethanol]7 mg/mL]false Purity: 98.95%
98.95

Gemigliptin Related Products

Signaling Pathway

DPP Signaling Pathways

DPP Signaling Pathway

Biological Activity

Description

Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
Targets
DPP-4 [1]
7.25 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03867942 Unknown status
Diabetes Mellitus Type 2|Dyslipidemias
LG Chem
 March 21 2019 Phase 1
NCT03565458 Unknown status
Type 2 Diabetes Mellitus
LG Chem
 April 5 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 489.36 Formula

C18H19F8N5O2
CAS No. 911637-19-9 SDF --
Smiles NC(CN1CC(F)(F)CCC1=O)CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 98 mg/mL ( (200.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 12 mg/mL

Ethanol : 7 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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