Home Metabolism Lipoxygenase inhibitor - COX inhibitor FPL 62064 For research use only.

FPL 62064

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.

FPL 62064 Chemical Structure

FPL 62064 Chemical Structure

CAS No. 103141-09-9

Purity & Quality Control

Batch: S075901 DMSO]53 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.57%
99.57

FPL 62064 Related Products

Biological Activity

Description FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.
Targets
seminal vesicle prostaglandin synthetase [1]
(Cell-free assay)		 RBL-1 cytosolic 5-LOX [1]
(Cell-free assay)
3.1 μM 3.5 μM

Chemical Information & Solubility

Molecular Weight 265.31 Formula
C16H15N3O
CAS No. 103141-09-9 SDF --
Smiles COC1=CC=C(C=C1)NC2=NN(C=C2)C3=CC=CC=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 53 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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