Home Microbiology CMV inhibitor Fialuridine For research use only.

Fialuridine

Synonyms: FIAU; DRG-0098; NSC 678514

Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.

Fialuridine Chemical Structure

Fialuridine Chemical Structure

CAS: 69123-98-4

Purity & Quality Control

Batch: E170901 DMSO] 74 mg/mL] false] Ethanol] 9 mg/mL] false] Water] Insoluble] false Purity: 99.02%
99.02

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Biological Activity

Description Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01764919 Terminated
Diabetic Foot Infection
BioMed Valley Discoveries Inc
 April 2013 Phase 2
NCT01705496 Terminated
Prosthetic Joint Infections
BioMed Valley Discoveries Inc
 August 2012 Phase 2
NCT01337466 Completed
Prosthesis Related Infections
BioMed Valley Discoveries Inc
 December 2010 Phase 1
NCT00982449 Completed
Hodgkin Lymphoma|Non Hodgkin Lymphoma|Kaposi''s Sarcoma|Gastric Cancer|Nasopharyngeal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI)
 December 2010 Not Applicable

Chemical Information & Solubility

Molecular Weight 372.09 Formula

C9H10FIN2O5
CAS No. 69123-98-4 SDF Download Fialuridine SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 74 mg/mL ( (198.87 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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