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Fezolinetant
Synonyms: ESN-364
Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle.
Fezolinetant Chemical Structure
CAS No. 1629229-37-3
Purity & Quality Control
Batch:
E010901
DMSO]72 mg/mL]false]Ethanol]9 mg/mL]false]Water]Insoluble]false
Purity:
99.64%
99.64
Fezolinetant Related Products
| Related Targets | NK1R | Click to Expand |
|---|---|---|
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ GPCR Compound Library | Click to Expand |
Biological Activity
| Description | Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle. | |
|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06206421 | Recruiting | Hot Flashes |
Astellas Pharma Inc |
February 22 2024 | Phase 3 |
| NCT06206408 | Recruiting | Hot Flashes |
Astellas Pharma Inc |
February 16 2024 | Phase 3 |
| NCT04793204 | Completed | Healthy Volunteers |
Astellas Pharma China Inc.|Astellas Pharma Inc |
March 24 2021 | Phase 1 |
| NCT04641260 | Completed | Healthy Subjects |
Astellas Pharma Global Development Inc.|Astellas Pharma Inc |
November 20 2020 | Phase 1 |
| NCT04482270 | Completed | Hepatic Impairment|Healthy Volunteers |
Astellas Pharma Global Development Inc.|Astellas Pharma Inc |
September 2 2020 | Phase 1 |
| NCT04476849 | Completed | Healthy Volunteers|Renal Impairment |
Astellas Pharma Global Development Inc.|Astellas Pharma Inc |
August 10 2020 | Phase 1 |
Chemical Information & Solubility
| Molecular Weight | 358.39 | Formula | C₁₆H₁₅FN₆OS |
| CAS No. | 1629229-37-3 | SDF | Download Fezolinetant SDF |
| Storage (From the date of receipt) | |||
|
In vitro |
DMSO : 72 mg/mL ( (200.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 9 mg/mL Water : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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