Home GPCR & G Protein Neurokinin Receptor antagonist - Neuraminidase antagonist Fezolinetant For research use only.

Fezolinetant

Synonyms: ESN-364

Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle.

Fezolinetant Chemical Structure

Fezolinetant Chemical Structure

CAS No. 1629229-37-3

Purity & Quality Control

Batch: E010901 DMSO]72 mg/mL]false]Ethanol]9 mg/mL]false]Water]Insoluble]false Purity: 99.64%
99.64

Fezolinetant Related Products

Biological Activity

Description Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle.
Targets
neurokinin 3 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06206421 Recruiting
Hot Flashes
Astellas Pharma Inc
 February 22 2024 Phase 3
NCT06206408 Recruiting
Hot Flashes
Astellas Pharma Inc
 February 16 2024 Phase 3
NCT04793204 Completed
Healthy Volunteers
Astellas Pharma China Inc.|Astellas Pharma Inc
 March 24 2021 Phase 1
NCT04641260 Completed
Healthy Subjects
Astellas Pharma Global Development Inc.|Astellas Pharma Inc
 November 20 2020 Phase 1
NCT04482270 Completed
Hepatic Impairment|Healthy Volunteers
Astellas Pharma Global Development Inc.|Astellas Pharma Inc
 September 2 2020 Phase 1
NCT04476849 Completed
Healthy Volunteers|Renal Impairment
Astellas Pharma Global Development Inc.|Astellas Pharma Inc
 August 10 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 358.39 Formula

C₁₆H₁₅FN₆OS
CAS No. 1629229-37-3 SDF Download Fezolinetant SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (200.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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