Home Neuronal Signaling Histamine Receptor antagonist Famotidine For research use only.

Famotidine

Synonyms: MK208

Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Famotidine Chemical Structure

Famotidine Chemical Structure

CAS No. 76824-35-6

Purity & Quality Control

Batch: S207801 DMSO]67 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.48%
99.48

Famotidine Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.
Targets
H2 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06054464 Active not recruiting
Healthy Volunteers
PMV Pharmaceuticals Inc
 September 19 2023 Phase 1
NCT04941755 Completed
Healthy Participants
Bristol-Myers Squibb
 June 25 2021 Phase 1
NCT04614974 Active not recruiting
Laryngomalacia|Gastro Esophageal Reflux
Reema Padia|University of Pittsburgh
 November 18 2020 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 337.45 Formula

C8H15N7O2S3
CAS No. 76824-35-6 SDF Download Famotidine SDF
Smiles C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (198.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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