Home Neuronal Signaling BACE inhibitor - Sodium Channel inhibitor Eslicarbazepine Acetate For research use only.

Eslicarbazepine Acetate

Synonyms: BIA 2093, Zebinix, Exalief, Stedesa, Aptiom

Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

Eslicarbazepine Acetate Chemical Structure

Eslicarbazepine Acetate Chemical Structure

CAS No. 236395-14-5

Purity & Quality Control

Batch: S465701 DMSO]59 mg/mL]false]Ethanol]11 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

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Signaling Pathway

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BACE Signaling Pathway

Biological Activity

Description Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
In Vivo
In vivo Eslicarbazepine acetate(ESL) has Anticonvulsant effects on the development of latrunculin A-induced seizures and paroxysmal EEG activity. ESL may also exhibit disease-modifying effects beyond suppressing just seizure activity, possibly by altering the development of a hyperexcitable network, as evidenced by the suppressed changes in glycine, taurine, glutamate and aspartate concentrations associated with an antiepileptogenic effect[1].
Animal Research Animal Models Adult NMRI or Swiss male mice
Dosages 100 mg/kg
Administration Oral administration

Chemical Information & Solubility

Molecular Weight 296.32 Formula

C17H16N2O3
CAS No. 236395-14-5 SDF Download Eslicarbazepine Acetate SDF
Smiles CC(=O)OC1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 59 mg/mL ( (199.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 11 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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