Home Neuronal Signaling Serotonin Transporter inhibitor - 5-HT Receptor inhibitor Escitalopram Oxalate For research use only.

Escitalopram Oxalate

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

Escitalopram Oxalate Chemical Structure

Escitalopram Oxalate Chemical Structure

CAS No. 219861-08-2

Purity & Quality Control

Escitalopram Oxalate Related Products

Biological Activity

Description Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Targets
5-HT [2]
0.89 nM(Ki)
In vitro
In vitro Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.[1] In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05730062 Not yet recruiting
Opioid Induced Respiratory Depression|Depressive Disorder|Anxiety Disorders
Leiden University Medical Center
 March 15 2023 Phase 1
NCT05210140 Unknown status
Depressive Disorder Major
University of Belgrade|Clinical Centre of Serbia|Institute of Mental Health Serbia|Military Medical Academy Belgrade Serbia
 July 16 2020 --
NCT04239339 Completed
Healthy
Rigshospitalet Denmark|University of Cambridge|Lundbeck Foundation
 April 28 2020 Phase 4
NCT03912974 Completed
Healthy
University Hospital Basel Switzerland
 July 4 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 414.43 Formula

C20H21FN2O.C2H2O4
CAS No. 219861-08-2 SDF Download Escitalopram Oxalate SDF
Smiles CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (200.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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