Home Protein Tyrosine Kinase ALK inhibitor Envonalkib For research use only.

Envonalkib

Synonyms: TQ-B3139, CT-71, Formula 1

Envonalkib(TQ-B3139, CT-71, Formula 1) is a potent and orally active inhibitor of ALK, that exhibits IC50 values of 1.96 nM, 35.1 nM, and 61.3 nM for wild-type and mutated L1196M and G1269S-ALK. Envonalkib is also used in the research of non-small cell lung cancer.

Envonalkib Chemical Structure

Envonalkib Chemical Structure

CAS No. 1621519-26-3

Purity & Quality Control

Batch: E186501 DMSO]100 mg/mL]false]Ethanol]50 mg/mL]false]Water]Insoluble]false Purity: 99.52%
99.52

Envonalkib Related Products

Signaling Pathway

ALK Signaling Pathways

ALK Signaling Pathway

Biological Activity

Description Envonalkib(TQ-B3139, CT-71, Formula 1) is a potent and orally active inhibitor of ALK, that exhibits IC50 values of 1.96 nM, 35.1 nM, and 61.3 nM for wild-type and mutated L1196M and G1269S-ALK. Envonalkib is also used in the research of non-small cell lung cancer.
Targets
WT ALK [1] ALK(L1196M) [1] ALK (G1269S) [1]
1.98 nM 35.1 nM 61.3 nM

Chemical Information & Solubility

Molecular Weight 506.40 Formula

C24H26Cl2FN5O2
CAS No. 1621519-26-3 SDF Download Envonalkib SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (197.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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