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Enapotamab vedotin
Synonyms: EnaV, HuMAX-AXL-ADC
Enapotamab vedotin (EnaV, HuMAX-AXL-ADC) is an AXL-specific human IgG1 antibody conjugated to the microtubule disrupting agent monomethyl auristatin E (MMAE) through a protease cleavable valine-citrulline (vc) linker.
CAS No. 1912424-97-5
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Purity & Quality Control
Batch:
D403801
Purity:
99%
Protein concentration: 7.118mg/ml
Endotoxin Level: ＜1EU/mg
99
Choose Selective Axl Inhibitors
| Name | Citation | Axl | Others |
|---|---|---|---|
| BMS-777607 | 57 | RON,Met,Tyro3 | |
| Bemcentinib (R428) | 124 | ||
| XL092 | 0 | VEGFR2,MER,MET | |
| UNC2025 | 7 | FLT3,Mer,TrkA | |
| Ningetinib | 0 | VEGFR2,c-Met | |
| Tamnorzatinib (ONO-7475) | 3 | Mer,FLT3 | |
| RU-301 | 0 | ||
| Sitravatinib (MGCD516) | 4 | DDR2,EPHA3,Mer | |
| CEP-40783 (RXDX-106) | 6 | c-Met,Tyro3,MER | |
| S49076 | 1 | Met,Mer,FGFR3 | |
| Merestinib (LY2801653) | 10 | DDR1,Met,DDR2 | |
| SGI-7079 | 3 | YES,Mer,Met | |
| UNC2025 HCl | 9 | Mer,FLT3,Tyro3 | |
| Dubermatinib(TP-0903) | 17 | ||
| NPS-1034 | 3 | Met | |
| LDC1267 | 9 | Mer,Tyro3 | |
| PF-07265807 | Mer |
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.
Biological Activity
| Description | Enapotamab vedotin (EnaV, HuMAX-AXL-ADC) is an AXL-specific human IgG1 antibody conjugated to the microtubule disrupting agent monomethyl auristatin E (MMAE) through a protease cleavable valine-citrulline (vc) linker. |
|---|
Product Details
| CAS No. | 1912424-97-5 |
|---|---|
| ADC antiody | Enapotamab |
| ADC cytotoxin | MMAE |
| Formulation | 1xPBS |
| Storage (From the date of receipt) |
Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
Comparison of Clones for
*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)
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