Home Transmembrane Transporters CFTR modulator Elexacaftor (VX-445) For research use only.

Elexacaftor (VX-445)

Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity.

Elexacaftor (VX-445) Chemical Structure

Elexacaftor (VX-445) Chemical Structure

CAS No. 2216712-66-0

Purity & Quality Control

Batch: S885101 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.67%
99.67

Elexacaftor (VX-445) Related Products

Signaling Pathway

CFTR Signaling Pathways

CFTR Signaling Pathway

Biological Activity

Description Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity.
Targets
CFTR [1]
In vitro
In vitro

The pendrin-dependent increase in cystic fibrosis transmembrane conductance regulator (CFTR) current is additive with the CFTR modulator elexacaftor.[2]
Cell Research Cell lines Human bronchial epithelial cells from DeltaF508/DeltaF508 Cystic Fibrosis patients (CF HBECs)
Concentrations 3 µM
Incubation Time 48 h
Method

Using Chamber recordings from DeltaF508/DeltaF508 CF HBEC epithelia were treated with the LIE triple combination for 48 h plus and minus 10 ng/mL IL-13 and/or 10 micromol/L niflumic acid (for 30 minutes) again. Transepithelial current (Isc) and conductance (Gt) were measured.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06331000 Not yet recruiting
Cystic Fibrosis
University Hospital Strasbourg France
 March 2024 --
NCT05519020 Recruiting
Cystic Fibrosis
Sheffield Teaching Hospitals NHS Foundation Trust
 July 27 2022 --
NCT03525548 Completed
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 August 3 2018 Phase 3
NCT03525444 Completed
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 June 15 2018 Phase 3

Chemical Information & Solubility

Molecular Weight 597.65 Formula

C26H34F3N7O4S
CAS No. 2216712-66-0 SDF --
Smiles CC1CC(N(C1)C2=C(C=CC(=N2)N3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)NS(=O)(=O)C4=CN(N=C4C)C)(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (167.32 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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