Home Neuronal Signaling BACE inhibitor Elenbecestat For research use only.

Elenbecestat

Synonyms: E2609

Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.

Elenbecestat Chemical Structure

Elenbecestat Chemical Structure

CAS No. 1388651-30-6

Purity & Quality Control

Elenbecestat Related Products

Signaling Pathway

BACE Signaling Pathways

BACE Signaling Pathway

Biological Activity

Description Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03055962 Completed
Healthy Participants
Eisai Co. Ltd.|Eisai Inc.
 February 14 2017 Phase 1
NCT02859207 Completed
Early Alzheimer''s Disease
Eisai Inc.
 August 2016 Phase 1
NCT02322021 Terminated
Alzheimer Disease|Dementia Alzheimer Type
Eisai Inc.|Biogen
 November 26 2014 Phase 2
NCT02222324 Completed
Healthy Subjects
Eisai Inc.
 August 2014 Phase 1
NCT02207790 Completed
Healthy Subjects
Eisai Inc.
 July 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 437.44 Formula

C19H18F3N5O2S
CAS No. 1388651-30-6 SDF --
Smiles CC1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(N=C4)C(F)F)F)N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 87 mg/mL ( (198.88 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 11 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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