Home Neuronal Signaling Histamine Receptor antagonist Doxepin HCl For research use only.

Doxepin HCl

Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo.

Doxepin HCl Chemical Structure

Doxepin HCl Chemical Structure

CAS No. 1229-29-4

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Doxepin HCl Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo.
In vitro
In vitro Doxepin inhibits the reuptake of serotonin and norepinephrine. Its actions of the reuptake of dopamine are negligible. Doxepin also has antagonistic effects at a variety of receptors including receptors of H1, H2, 5-HT1, 5-HT2, α1-adrenergic and mACh.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01156142 Completed
Head and Neck Cancer|Mucositis|Oral Complications of Radiation Therapy|Pain
Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI)
 December 2010 Phase 3

Chemical Information & Solubility

Molecular Weight 315.84 Formula

C19H21NO.HCl
CAS No. 1229-29-4 SDF Download Doxepin HCl SDF Download Doxepin HCl SDF
Smiles CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (199.46 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 63 mg/mL

Ethanol : 63 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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