Home Biosimilar Antibodies Protein Tyrosine Kinase HER2 null -EGFR chemical Disitamab vedotin For research use only.
Not for use in humans.

Disitamab vedotin

Synonyms: RC-48, RC 480-ADC

Disitamab Vedotin (RC-48 ,RC 480-ADC) is an antibody-drug conjugate(ADC) composed of anti-[ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] humanized monoclonal antibody, conjugated to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Disitamab Vedotin has the potential for use in solid tumors mainly in advanced breast cancer.

Disitamab vedotin

CAS No. 2136633-23-1

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Purity & Quality Control

Batch: D404901 Purity: 99.17% Protein concentration: 3.3mg/ml Endotoxin Level: ＜1EU/mg
99.17

Choose Selective HER2 Inhibitors

Name Citation HER2 Others
Canertinib (CI-1033) 46 EGFR
CP-724714 108
Sapitinib (AZD8931) 46 ErbB3,EGFR
CUDC-101 22 EGFR,HDAC,HDAC1
Mubritinib (TAK 165) 38
AEE788 (NVP-AEE788) 13 EGFR,c-Abl,FLT1
AC480 (BMS-599626) 10 HER1,HER4
TAK-285 4 EGFR/HER1,HER4,MEK1
Tyrphostin AG 879 3 Trk
Poziotinib 33 HER1,HER4
HER2-Inhibitor-1
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description Disitamab Vedotin (RC-48 ,RC 480-ADC) is an antibody-drug conjugate(ADC) composed of anti-[ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)] humanized monoclonal antibody, conjugated to monomethylauristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Disitamab Vedotin has the potential for use in solid tumors mainly in advanced breast cancer.

Product Details

CAS No. 2136633-23-1
DAR 3.8
ADC antiody Disitamab
ADC cytotoxin MMAE
Formulation 1xPBS
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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