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Dextran sulfate sodium (DSS)
Synonyms: Dextran sulfate sodium salt
Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.Dextran sulfate sodium (DSS) can be used to induce animal models of Enteritis, Ulcerative Colitis.
Dextran sulfate sodium (DSS) Chemical Structure
CAS No. 9011-18-1
Purity & Quality Control
Batch:
Purity:
99%
99
Dextran sulfate sodium (DSS) Related Products
| Related Targets | HIV-1 capsid HIV-1 caspid | Click to Expand |
|---|---|---|
| Related Products | Pepstatin A Limonin Temsavir (BMS-626529) | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Protease Inhibitor Library Ubiquitination Compound Library | Click to Expand |
Signaling Pathway
Biological Activity
| Description | Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells.Dextran sulfate sodium (DSS) can be used to induce animal models of Enteritis, Ulcerative Colitis. | |
|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05885490 | Not yet recruiting | Head Cancer Neck |
Royal Marsden NHS Foundation Trust |
July 2024 | -- |
| NCT06381180 | Not yet recruiting | Post Traumatic Stress Disorder|Cannabis Use|Suicide|Veterans|Marijuana |
Wayne State University |
May 1 2024 | Phase 1|Phase 2 |
| NCT06348264 | Recruiting | Salivary Gland Neoplasm Duct |
Peking University First Hospital|Jiangsu Hengrui Pharmaceutical Co. Ltd.|Beijing Biote Pharmaceutical Co.Ltd |
March 30 2024 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 36-50Kda | Formula | |
| CAS No. | 9011-18-1 | SDF | -- |
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
Water : 100 mg/mL DMSO : 50 mg/mL ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Preparing Stock Solutions
Molarity Calculator
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
mg/kg
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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