Home Endocrinology & Hormones Androgen Receptor antagonist Deutenzalutamide For research use only.

Deutenzalutamide

Synonyms: HC-1119, MDV3100

Deutenzalutamide (HC-1119, MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. It can be used in a treatment of advanced prostate cancer.

Deutenzalutamide Chemical Structure

Deutenzalutamide Chemical Structure

CAS: 1443331-82-5

Purity & Quality Control

Batch: E150201 DMSO] 93 mg/mL] false] Ethanol] 8 mg/mL] false] Water] Insoluble] false Purity: 99.33%
99.33

Deutenzalutamide Related Products

Signaling Pathway

Androgen Receptor Signaling Pathways

Androgen Receptor Signaling Pathway

Choose Selective Androgen Receptor Inhibitors

Biological Activity

Description Deutenzalutamide (HC-1119, MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. It can be used in a treatment of advanced prostate cancer.
Targets
Androgen Receptor [1]
36 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04986176 Unknown status
COVID-19 Respiratory Infection
Applied Biology Inc.|Hinova Pharmaceuticals Inc.
 April 15 2022 Phase 3
NCT01901133 Completed
Pharmacokinetics of MDV3100|Healthy Subjects|Kidney Diseases
Astellas Pharma Europe B.V.|Medivation Inc.|Astellas Pharma Inc
 October 2011 Phase 1
NCT01913379 Completed
Healthy Subjects|Pharmacokinetics|Drug-Drug Interaction
Astellas Pharma Europe B.V.|Medivation Inc.|Astellas Pharma Inc
 August 2011 Phase 1
NCT01911715 Completed
Healthy Subjects|Pharmacokinetics of MDV3100
Astellas Pharma Europe B.V.|Medivation Inc.|Astellas Pharma Inc
 April 2011 Phase 1
NCT00510718 Completed
Prostate Cancer|Hormone Refractory Prostate Cancer
Pfizer|Astellas Pharma Inc|Medivation LLC a wholly owned subsidiary of Pfizer Inc.
 July 23 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 467.46 Formula

C21H13D3F4N4O2S
CAS No. 1443331-82-5 SDF Download Deutenzalutamide SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (198.94 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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