Home Immunology & Inflammation Complement System inhibitor Danicopan For research use only.

Danicopan

Synonyms: ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040

Danicopan is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Danicopan Chemical Structure

Danicopan Chemical Structure

CAS No. 1903768-17-1

Purity & Quality Control

Danicopan Related Products

Biological Activity

Description Danicopan is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Targets
alternative pathway of complement (APC) [1] human Factor D [1]
(Cell-free assay)
0.54 nM(Kd)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05019521 Active not recruiting
Geographic Atrophy
Alexion Pharmaceuticals Inc.
 August 23 2021 Phase 2
NCT04469465 Completed
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals Inc.
 December 16 2020 Phase 3
NCT04451434 Completed
Healthy
Alexion Pharmaceuticals Inc.
 August 17 2020 Phase 1
NCT04551599 Completed
Healthy
Alexion Pharmaceuticals Inc.
 February 21 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 580.41 Formula

C26H23BrFN7O3
CAS No. 1903768-17-1 SDF --
Smiles CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4CC(CC4C(=O)NC5=NC(=CC=C5)Br)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (172.29 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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