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D3-βArr

Name: D3-βArr
Brand: Selleck Chemicals
SKU: S0319
Rating: 5 (1 reviews)

Synonyms: NCGC00379308

Catalog No.S0319 Purity:99.96%

D3-βArr(NCGC00379308) is a positive allosteric modulator of thyrotropin receptor (TSHR) that modulates TSH-induced β-Arr 1 translocation.

D3-βArr Chemical Structure

CAS No. 662164-09-2

Purity & Quality Control

Batch: S031901 DMSO]67 mg/mL]false]Ethanol]33 mg/mL]false]Water]Insoluble]false Purity: 99.96%

99.96

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Biological Activity

Description

D3-βArr(NCGC00379308) is a positive allosteric modulator of thyrotropin receptor (TSHR) that modulates TSH-induced β-Arr 1 translocation.

Targets

TSHR ^[1]

References

[1] Neumann S, et al. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.

Chemical Information & Solubility

Molecular Weight	333.43	Formula	C₂₀H₂₃N₅
CAS No.	662164-09-2	SDF	--
Smiles	CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCNCC4
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 67 mg/mL ( (200.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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