Home GPCR & G Protein Ras inhibitor garsorasib (D-1553 ) For research use only.

garsorasib (D-1553 )

Garsorasib (D-1553 ) is a potent and selective oral KRASG12C inhibitor with antitumor activity. It has the potential to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC).

garsorasib (D-1553 ) Chemical Structure

garsorasib (D-1553 ) Chemical Structure

CAS No. 2559761-14-5

Purity & Quality Control

Batch: E157801 DMSO]100 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.07%
99.07

garsorasib (D-1553 ) Related Products

Signaling Pathway

Ras Signaling Pathways

Ras Signaling Pathway

Biological Activity

Description Garsorasib (D-1553 ) is a potent and selective oral KRASG12C inhibitor with antitumor activity. It has the potential to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC).
Targets
KRAS-G12C [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06233916 Completed
Mass Balance Study
InventisBio Co. Ltd
 December 8 2023 Phase 1
NCT06105255 Active not recruiting
Healthy Male
InventisBio Co. Ltd
 May 24 2023 Phase 1
NCT06166836 Recruiting
Solid Tumor
InxMed (Shanghai) Co. Ltd.|InventisBio Co. Ltd
 October 12 2022 Phase 1|Phase 2
NCT05492045 Recruiting
NSCLC
InventisBio Co. Ltd
 September 13 2022 Phase 1|Phase 2
NCT05383898 Active not recruiting
NSCLC
InventisBio Co. Ltd
 March 16 2021 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 598.65 Formula

C32H32F2N8O2
CAS No. 2559761-14-5 SDF Download garsorasib (D-1553 ) SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (167.04 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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