Home GPCR & G Protein S1P Receptor agonist CYM5541 For research use only.

CYM5541

Synonyms: ML249

CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.

CYM5541 Chemical Structure

CYM5541 Chemical Structure

CAS No. 945128-26-7

Purity & Quality Control

Batch: S655201 Ethanol]63 mg/mL]false]DMSO]32 mg/mL]false]Water]Insoluble]false Purity: 98.16%
98.16

CYM5541 Related Products

Signaling Pathway

S1P Receptor Signaling Pathways

S1P Receptor Signaling Pathway

Biological Activity

Description CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.
Targets
S1P3 [1]

Chemical Information & Solubility

Molecular Weight 316.44 Formula

C19H28N2O2
CAS No. 945128-26-7 SDF --
Smiles C1CCC(CC1)N(C2CCCCC2)C(=O)C3=NOC(=C3)C4CC4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Ethanol : 63 mg/mL

DMSO : 32 mg/mL ( (101.12 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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