Home Endocrinology & Hormones Glucocorticoid Receptor agonist Clobetasol propionate For research use only.

Clobetasol propionate

Synonyms: CGP9555, CCl 4725

Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.

Clobetasol propionate Chemical Structure

Clobetasol propionate Chemical Structure

CAS No. 25122-46-7

Purity & Quality Control

Clobetasol propionate Related Products

Biological Activity

Description Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
Targets
Glucocorticoid receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03179605 Terminated
Psoriasis
Primus Pharmaceuticals|Prosoft Clinical
 May 2 2017 Phase 2
NCT00757874 Completed
Vulvar Lichen Sclerosus
Deana Funaro|Astellas Pharma Inc|St. Justine''s Hospital
 April 2006 Phase 2

Chemical Information & Solubility

Molecular Weight 466.97 Formula

C25H32ClFO5
CAS No. 25122-46-7 SDF Download Clobetasol propionate SDF
Smiles CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (199.15 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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