Home MAPK MAPKAPK2 inhibitor Gamcemetinib (CC-99677) For research use only.

Gamcemetinib (CC-99677)

Synonyms: BMS-986371

Gamcemetinib (CC-99677,BMS-986371) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) (MAPKAPK2 (MK2)) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM).

Gamcemetinib (CC-99677) Chemical Structure

Gamcemetinib (CC-99677) Chemical Structure

CAS No. 1887069-10-4

Purity & Quality Control

Batch: E165701 DMSO]94 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.00%
99.00

Gamcemetinib (CC-99677) Related Products

Biological Activity

Description Gamcemetinib (CC-99677,BMS-986371) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) (MAPKAPK2 (MK2)) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM).
Targets
MAPKAPK2 [1]
156.3 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05284890 Completed
Healthy Volunteers
Bristol-Myers Squibb
 May 12 2022 Phase 1
NCT04958291 Completed
Healthy Volunteers
Celgene
 August 3 2021 Phase 1
NCT03554993 Completed
Healthy Volunteer
Celgene
 May 23 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 469.95 Formula

C22H20ClN5O3S
CAS No. 1887069-10-4 SDF Download Gamcemetinib (CC-99677) SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 94 mg/mL ( (200.02 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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