Home Ubiquitin E3 Ligase inhibitor CC-90009 For research use only.

CC-90009

CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.

CC-90009 Chemical Structure

CC-90009 Chemical Structure

CAS No. 1860875-51-9

Purity & Quality Control

CC-90009 Related Products

Signaling Pathway

E3 Ligase Signaling Pathways

E3 Ligase Signaling Pathway

Biological Activity

Description CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.
Targets
CRBN [1]
In vitro
In vitro

CC-90009 is a new type of cereblon (CRBN) E3 ligase regulator, which specifically aims at proteasome degradation of GSPT1.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Cell Research Cell lines NB4 cells
Concentrations 0.001, 0.01, 0.1, 1 μM
Incubation Time 4 h
Method

NB4 cells were treated for 4 h and then processed for Western blotting.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02848001 Active not recruiting
Leukemia Myeloid Acute|Myelodysplastic Syndromes
Celgene
 November 14 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 461.85 Formula

C22H18ClF2N3O4
CAS No. 1860875-51-9 SDF --
Smiles FC(F)(C(=O)NCC1=CC2=C(C=C1)C(=O)N(C2)C3CCC(=O)NC3=O)C4=CC=C(Cl)C=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (199.19 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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