Home Endocrinology & Hormones RAAS inhibitor - ACE inhibitor Captopril For research use only.

Captopril

Synonyms: SQ 14225,Capoten

Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

Captopril Chemical Structure

Captopril Chemical Structure

CAS No. 62571-86-2

Purity & Quality Control

Captopril Related Products

Signaling Pathway

RAAS Signaling Pathways

RAAS Signaling Pathway

Biological Activity

Description Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
Targets
ACE [1]
6 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04964050 Withdrawn
Healthy Volunteers
GlaxoSmithKline
 April 21 2022 Phase 1
NCT04878315 Withdrawn
Healthy Volunteers
GlaxoSmithKline
 February 13 2022 Phase 1
NCT05826080 Recruiting
Primary Aldosteronism|Aldosterone-Producing Adenoma|Idiopathic Hyperaldosteronism
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
 September 1 2021 --
NCT04355429 Unknown status
Pneumonia|Coronavirus Infection|COVID-19
Assistance Publique - Hôpitaux de Paris
 May 5 2020 Phase 2
NCT04224675 Unknown status
Aneurysm
Onassis Cardiac Surgery Centre
 March 7 2020 Not Applicable

Chemical Information & Solubility

Molecular Weight 217.29 Formula

C9H15NO3S
CAS No. 62571-86-2 SDF Download Captopril SDF
Smiles CC(CS)C(=O)N1CCCC1C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (197.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 43 mg/mL

Water : 2 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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