Home Cytoskeletal Signaling Integrin inhibitor Bexotegrast For research use only.

Bexotegrast

Synonyms: PLN-74809

Bexotegrast(PLN-74809) is potent dual selective inhibitor of αvβ6 and αvβ1 integrins with Kd of 5.7 nM and 3.4 nM, respectively. It has antifibrogenic effects, blocks multiple TGF-β activation pathways in the fibrotic lung, and is useful for researching fibrosis, including idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Bexotegrast Chemical Structure

Bexotegrast Chemical Structure

CAS No. 2376257-44-0

Purity & Quality Control

Batch: E138501 DMSO]99 mg/mL]false]Water]99 mg/mL]false]Ethanol]99 mg/mL]false Purity: 99.40%
99.40

Bexotegrast Related Products

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Integrin Signaling Pathway

Biological Activity

Description Bexotegrast(PLN-74809) is potent dual selective inhibitor of αvβ6 and αvβ1 integrins with Kd of 5.7 nM and 3.4 nM, respectively. It has antifibrogenic effects, blocks multiple TGF-β activation pathways in the fibrotic lung, and is useful for researching fibrosis, including idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Chemical Information & Solubility

Molecular Weight 492.61 Formula

C27H36N6O3
CAS No. 2376257-44-0 SDF Download Bexotegrast SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 99 mg/mL ( (200.97 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 99 mg/mL

Ethanol : 99 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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