Home Metabolism Factor Xa inhibitor Betrixaban For research use only.

Betrixaban

Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.

Betrixaban Chemical Structure

Betrixaban Chemical Structure

CAS No. 330942-05-7

Purity & Quality Control

Batch: S538801 DMSO]35 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.31%
99.31

Betrixaban Related Products

Signaling Pathway

Factor Xa Signaling Pathways

Factor Xa Signaling Pathway

Biological Activity

Description Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.
Targets
Factor Xa [1]
(Cell-free assay)
1.5 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03346083 Terminated
VTE Prophylaxis
Alexion Pharmaceuticals Inc.|Portola Pharmaceuticals LLC (a wholly owned subsidiary of Alexion Pharmaceuticals)
 July 13 2018 Phase 1
NCT02596100 Completed
Healthy
Portola Pharmaceuticals|Alexion Pharmaceuticals Inc.
 September 2015 Phase 1
NCT00999336 Completed
Renal Impairment
Portola Pharmaceuticals|Merck Sharp & Dohme LLC|Alexion Pharmaceuticals Inc.
 July 31 2009 Phase 1

Chemical Information & Solubility

Molecular Weight 451.91 Formula

C23H22ClN5O3
CAS No. 330942-05-7 SDF --
Smiles CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 35 mg/mL ( (77.44 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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