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Etrasimod(APD334)

Name: Etrasimod(APD334)
Brand: Selleck Chemicals
SKU: E2363
Rating: 5 (1 reviews)

Synonyms: APD334

Catalog No.E2363 Purity:99.59%

Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.

Etrasimod(APD334) Chemical Structure

CAS No. 1206123-37-6

Purity & Quality Control

Batch: E236301 DMSO]92 mg/mL]false]Ethanol]92 mg/mL]false]Water]Insoluble]false Purity: 99.59%

99.59

Etrasimod(APD334) Related Products

Related Targets	S1PR1 S1PR4 S1PR5 S1PR2	Click to Expand
Related Products	JTE 013 PF 429242	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ GPCR Compound Library	Click to Expand

Signaling Pathway

S1P Receptor Signaling Pathway

Biological Activity

Description	Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05287126	Recruiting	Ulcerative Colitis	Pfizer\|Arena is a wholly owned subsidiary of Pfizer	December 16 2022	Phase 2
NCT04706793	Completed	Ulcerative Colitis	Pfizer\|Arena is a wholly owned subsidiary of Pfizer	December 25 2020	Phase 3
NCT03155932	Terminated	Primary Biliary Cholangitis	Arena Pharmaceuticals	December 29 2017	Phase 2
NCT02536404	Completed	Ulcerative Colitis	Arena Pharmaceuticals	January 25 2016	Phase 2

References

[1] Currò D, et al. Front Pharmacol. 2017 Jun 23;8:400.

Chemical Information & Solubility

Molecular Weight	457.49	Formula	C₂₆H₂₆F₃NO₃
CAS No.	1206123-37-6	SDF	Download Etrasimod(APD334) SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 92 mg/mL ( (201.09 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 92 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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