For research use only. Not for use in humans.

Anti-PCSK9 (RG7652)

Synonyms: RG7652 Cat.No.A3024

Anti-PCSK9 (RG7652) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). It exhibits potential efficacy in coronary heart disease (CHD). MW :144.84 KD.

Anti-PCSK9 (RG7652)

Quality Control

Specificity

Name	Citation	PCSK9
PF-06446846	0	+++
PF-06446846 hydrochloride	0	✔
SBC-110736	0	✔
R-IMPP	0	✔
SBC-115076	9	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-PCSK9 (RG7652) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). It exhibits potential efficacy in coronary heart disease (CHD). MW :144.84 KD.
References	https://pubmed.ncbi.nlm.nih.gov/28343601/#:~:text=RG7652%20(MPSK3169A)%2C%20a%20fully,density%20lipoprotein%20(LDL)%20receptor.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Isotype	Human IgG1
Source	CHO
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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