Home DNA Damage/DNA Repair Topoisomerase inhibitor Amsacrine hydrochloride For research use only.

Amsacrine hydrochloride

Synonyms: m-AMSA, acridinyl anisidide

Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.

Amsacrine hydrochloride Chemical Structure

Amsacrine hydrochloride Chemical Structure

CAS No. 54301-15-4

Purity & Quality Control

Amsacrine hydrochloride Related Products

Signaling Pathway

Topoisomerase Signaling Pathways

Topoisomerase Signaling Pathway

Biological Activity

Description Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.
Targets
Topo II [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04997980 Completed
Out-Of-Hospital Cardiac Arrest
IRCCS Policlinico S. Matteo|University of the Basque Country (UPV/EHU)|Oslo University Hospital|The Hospital of Vestfold
 January 1 2015 --

Chemical Information & Solubility

Molecular Weight 429.92 Formula

C21H20ClN3O3S
CAS No. 54301-15-4 SDF --
Smiles COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 85 mg/mL ( (197.71 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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