Home Cell Cycle Ras inhibitor Sotorasib (AMG510) racemate For research use only.

Sotorasib (AMG510) racemate

Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.

Sotorasib (AMG510) racemate Chemical Structure

Sotorasib (AMG510) racemate Chemical Structure

CAS No. 2252403-56-6

Purity & Quality Control

Sotorasib (AMG510) racemate Related Products

Signaling Pathway

Ras Signaling Pathways

Ras Signaling Pathway

Biological Activity

Description Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.
Targets
KRAS G12Cv [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06061523 Withdrawn
Healthy Participants
Amgen
 July 15 2024 Phase 1
NCT05920356 Recruiting
Non-Small Cell Lung Cancer (NSCLC)
Amgen
 November 16 2023 Phase 3
NCT06314763 Completed
Drug Drug Interaction Study
Radboud University Medical Center|Amgen
 November 9 2023 Phase 4
NCT05497557 Completed
Healthy Volunteers
Amgen
 July 14 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 560.59 Formula

C30H30F2N6O3
CAS No. 2252403-56-6 SDF --
Smiles CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (178.38 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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