Home MAPK MEK inhibitor SL-327 For research use only.

SL-327

SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.

SL-327 Chemical Structure

SL-327 Chemical Structure

CAS No. 305350-87-2

Purity & Quality Control

SL-327 Related Products

Signaling Pathway

MEK Signaling Pathways

MEK Signaling Pathway

Biological Activity

Description SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.
Targets
MEK1 [3] MEK2 [3] AP-1 [3]
0.18 μM 0.22 μM 2.03 μM
In vitro
In vitro

SL327 is a structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII. [1]
In Vivo
In vivo

SL327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. [2] SL327 (30 mg/kg) significantly impairs spatial learning in mice. [3] SL327 (50 mg/kg) blocks cocaine-induced properties. [4]
Animal Research Animal Models Fear conditioning experiments in male Spague-Dawley rats.
Dosages 10-100 mg/Kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 335.35 Formula

C16H12F3N3S
CAS No. 305350-87-2 SDF Download SL-327 SDF
Smiles C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (199.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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