Home Others BACE - Other chemical Pamidronate Disodium For research use only.

Pamidronate Disodium

Synonyms: CGP 23339AE

Pamidronate Disodium (CGP 23339AE) is a nitrogen containing bisphosphonate, used to prevent osteoporosis.Pamidronate Disodium is a inhibitor of bone resorption factor.

Pamidronate Disodium Chemical Structure

Pamidronate Disodium Chemical Structure

CAS No. 57248-88-1

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Pamidronate Disodium Related Products

Signaling Pathway

BACE Signaling Pathways

BACE Signaling Pathway

Biological Activity

Description Pamidronate Disodium (CGP 23339AE) is a nitrogen containing bisphosphonate, used to prevent osteoporosis.Pamidronate Disodium is a inhibitor of bone resorption factor.
In vitro
In vitro Pamidronate increases OPG mRNA levels and protein secretion by hOB by up to 2- to 3-fold in a dose-dependent fashion with a maximum effect at 1 µM after 72 hours. Artemisinin prevents the inhibitory effects of the glucocorticoid dexamethasone on OPG mRNA and protein production. Pamidronate induces type I collagen secretion and alkaline phosphatase activity by 2-fold. [1] Pamidronate has a more pronounced calcium-lowering action than etidronate (etidronic acid) and clodronate (clodronic acid) and provides a longer period of normocalcaemic remission. [2] Pamidronate (APD) dose-dependently inhibits resorption of calcium phosphate films by equine OCLs with an IC(50) of 0.58 μM in one horse. Pamidronate also dose-dependently inhibits the number of OCLs present in BM cultures after 7 days. [3]
In Vivo
In vivo Pamidronate administration significantly suppresses this increase below the control level in the tibia and distal femur of oophorectomized rats. Pamidronate significantly increases bone density and ash weight in both sham-operated and oophorectomized rats. [4] Pamidronate inhibits all significant effects of growth hormone (GH) and it also decreases the IGF-I levels in rats treated with growth hormone (GH). Pamidronate itself results in increased the bone density and ash weight of the tibia and decreased urinary DPD excretion. [5]

Chemical Information & Solubility

Molecular Weight 279.03 Formula

C3H9NNa2O7P2
CAS No. 57248-88-1 SDF Download Pamidronate Disodium SDF
Smiles C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 56 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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