Home Endocrinology & Hormones 5-alpha Reductase inhibitor Finasteride For research use only.

Finasteride

Synonyms: MK-906

Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).

Finasteride Chemical Structure

Finasteride Chemical Structure

CAS No. 98319-26-7

Purity & Quality Control

Finasteride Related Products

Signaling Pathway

5-alpha Reductase Signaling Pathways

5-alpha Reductase Signaling Pathway

Biological Activity

Description Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).
Targets
5-α reductase [1]
10.2 nM(Ki)
In vitro
In vitro Finasteride binds to the type 2 isozyme-NADPH complex to form a ternary complex with Ki of 1.19 nM, which then rearranges to a high affinity complex (E:I) with a pseudo first order rate constant of 1.62 ms. [1] Finasteride dose-dependently inhibits the growth rate of the LnCap cell line. [2] Finasteride markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells. [3]
In Vivo
In vivo Finasteride induces dosage-related incidences of hypospadias (penischisis) in male offspring with a threshold dosage level near 0.1 mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats. Finasteride also causes decreased anogenital distance in male offspring in male rats. [4] Finasteride and castration decreases prostate weight at day 21 by 65% and 93%, respectively, in rats. Finasteride has no significant effect on DNA content after 4 days and decreases DNA content by a maximum of 52% at 14 days in rats. Finasteride causes a less intense increase in staining in which 16% of epithelial cells stained for tissue transglutaminase on day 9 with a return to baseline by day 14 in rats. Finasteride-induced staining is less intense with peak staining at day 4 (0.7% of epithelial cells) and a return to control values by day 9 in rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04288427 Recruiting
Benign Prostatic Hyperplasia|Prostate Hyperplasia|Prostate Disease|Prostate Hypertrophy|Prostate Pain|Lower Urinary Tract Symptoms|Urinary Obstruction|Urinary Tract Disease
Beth Israel Deaconess Medical Center|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 September 25 2020 Not Applicable
NCT03669692 Withdrawn
Prostatic Hyperplasia Benign|Metabolic Syndrome
Complexo Hospitalario Universitario de A Coruña
 July 10 2018 Not Applicable
NCT02824380 Completed
Androgenic Alopecia
Dong-A ST Co. Ltd.
 July 2016 Phase 1
NCT02146937 Withdrawn
Detectable Prostate Nodules
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 March 2014 Phase 2
NCT01703520 Completed
Male Breast Cancer
Organon and Co|Institute for Applied Economics and Health Research Aps
 May 1 2011 --

Chemical Information & Solubility

Molecular Weight 372.54 Formula

C23H36N2O2
CAS No. 98319-26-7 SDF Download Finasteride SDF
Smiles CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 75 mg/mL ( (201.32 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 75 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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