Home Neuronal Signaling P2 Receptor modulator Clopidogrel (SR-25990C) Bisulfate For research use only.

Clopidogrel (SR-25990C) Bisulfate

Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent.

Clopidogrel (SR-25990C) Bisulfate Chemical Structure

Clopidogrel (SR-25990C) Bisulfate Chemical Structure

CAS No. 120202-66-6

Purity & Quality Control

Clopidogrel (SR-25990C) Bisulfate Related Products

Signaling Pathway

P2 Receptor Signaling Pathways

P2 Receptor Signaling Pathway

Biological Activity

Description Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent.
Targets
P2Y12 [1]
In vitro
In vitro Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]
Experimental Result Images Methods Biomarkers Images PMID
Western blot ATF2 / ATF3 / ATF4 / ATF6 TRIB3 / CHOP 24058556
In Vivo
In vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05723926 Not yet recruiting
Atrial Fibrillation|Oral Anticoagulation|Stroke|Implant
Javelin Medical|Population Health Research Institute
 January 20 2025 Not Applicable
NCT06047002 Recruiting
Peripheral Arterial Disease
University of Leicester
 September 29 2022 --
NCT05166538 Unknown status
Multi Vessel Coronary Artery Disease
Yonsei University
 February 1 2022 Phase 4
NCT05162053 Completed
Acute Coronary Syndrome
Jiangsu vcare pharmaceutical technology co. LTD
 December 9 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 419.9 Formula

C16H16ClNO2S.H2SO4
CAS No. 120202-66-6 SDF Download Clopidogrel (SR-25990C) Bisulfate SDF
Smiles COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (197.66 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Clopidogrel (SR-25990C) Bisulfate | Clopidogrel (SR-25990C) Bisulfate ic50 | Clopidogrel (SR-25990C) Bisulfate price | Clopidogrel (SR-25990C) Bisulfate cost | Clopidogrel (SR-25990C) Bisulfate solubility dmso | Clopidogrel (SR-25990C) Bisulfate purchase | Clopidogrel (SR-25990C) Bisulfate manufacturer | Clopidogrel (SR-25990C) Bisulfate research buy | Clopidogrel (SR-25990C) Bisulfate order | Clopidogrel (SR-25990C) Bisulfate mouse | Clopidogrel (SR-25990C) Bisulfate chemical structure | Clopidogrel (SR-25990C) Bisulfate mw | Clopidogrel (SR-25990C) Bisulfate molecular weight | Clopidogrel (SR-25990C) Bisulfate datasheet | Clopidogrel (SR-25990C) Bisulfate supplier | Clopidogrel (SR-25990C) Bisulfate in vitro | Clopidogrel (SR-25990C) Bisulfate cell line | Clopidogrel (SR-25990C) Bisulfate concentration | Clopidogrel (SR-25990C) Bisulfate nmr