Home Neuronal Signaling Histamine Receptor antagonist Cimetidine For research use only.

Cimetidine

Synonyms: SKF-92334

Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Cimetidine Chemical Structure

Cimetidine Chemical Structure

CAS No. 51481-61-9

Purity & Quality Control

Batch: S184501 DMSO]51 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false Purity: 99.88%
99.88

Cimetidine Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.
Targets
Histamine H2 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06056583 Recruiting
Lactation
University of Washington|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 December 4 2023 Phase 4
NCT01536249 Completed
Amyotrophic Lateral Sclerosis
Knopp Biosciences
 March 2012 Phase 1
NCT01169012 Completed
Myelodysplastic Syndrome|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelomonocytic Leukemia
UNC Lineberger Comprehensive Cancer Center|Genzyme a Sanofi Company
 September 2010 Phase 1
NCT00475059 Completed
Kidney Transplantation
Centre Hospitalier Universitaire de Saint Etienne
 March 2007 Not Applicable

Chemical Information & Solubility

Molecular Weight 252.34 Formula

C10H16N6S
CAS No. 51481-61-9 SDF Download Cimetidine SDF
Smiles CC1=C(N=CN1)CSCCNC(=NC)NC#N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (202.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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