Home Metabolism FAAH inhibitor Biochanin A For research use only.

Biochanin A

Synonyms: 4-Methylgenistein

Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.

Biochanin A Chemical Structure

Biochanin A Chemical Structure

CAS No. 491-80-5

Purity & Quality Control

Biochanin A Related Products

Signaling Pathway

FAAH Signaling Pathways

FAAH Signaling Pathway

Biological Activity

Description Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.
Targets
FAAH (rat) [2] FAAH (mouse) [1] FAAH (human) [2] EGFR [1]
1.4 μM 1.8 μM 2.4 μM 91.5 μM
In vitro
In vitro Biochanin A has been reported to inhibit protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM [1] Biochanin A inhibits the hydrolysis of 0.5 μM anandamide by mouse, rat and human fatty acid amide hydrolase (FAAH) with IC50 values of 1.8, 1.4 and 2.4 μM respectively. [2] Biochanin A inhibits both serum and EGF-stimulated growth of LNCaP and DU-145 cells (IC50 values from 8.0 to 27 micrograms/ml for serum and 4.3 to 15 micrograms/ml for EGF), but has no significant effect of the EGF receptor tyrosine autophosphorylation. [3]
In Vivo
In vivo LD50: Mice 63mg/kg (i.p.) [4]

Chemical Information & Solubility

Molecular Weight 284.26 Formula

C16H12O5
CAS No. 491-80-5 SDF Download Biochanin A SDF
Smiles COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (197.0 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 16 mg/mL

Water : Insoluble


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In vivo
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