Home Neuronal Signaling Adenosine Kinase inhibitor 5-Iodotubercidin For research use only.

5-Iodotubercidin

Synonyms: NSC 113939, 5-ITu

5-Iodotubercidin (NSC 113939, 5-ITu) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

5-Iodotubercidin Chemical Structure

5-Iodotubercidin Chemical Structure

CAS No. 24386-93-4

Purity & Quality Control

5-Iodotubercidin Related Products

Biological Activity

Description 5-Iodotubercidin (NSC 113939, 5-ITu) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
Targets
adenosine kinase [1]
In vitro
In vitro

5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms[2].
Experimental Result Images Methods Biomarkers Images PMID
Western blot A1 receptor p-p53 / p53 / p-ATM / ATM / p-Chk2 / Chk2 25354767
Immunofluorescence AURKA / pAURKA 27562071
In Vivo
In vivo

5-Iodotubercidin is a potent inhibitor of adenosine kinase in the rat brain.. 5-iodotubercidin (1 mg/kg, i.p.) administered prior to an ischemic episode, fails to provide a degree of cerebroprotection, assessed either by locomotor or histopathological indices Even though 5-iodotubercidin administration is known to enhance extracellular adenosine levels in brain slices[1].
Animal Research Animal Models Male Mongolian gerbils
Dosages 1, 2.5 and 5 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 392.15 Formula

C11H13IN4O4
CAS No. 24386-93-4 SDF Download 5-Iodotubercidin SDF
Smiles C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)I
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 78 mg/mL ( (198.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy 5-Iodotubercidin | 5-Iodotubercidin supplier | purchase 5-Iodotubercidin | 5-Iodotubercidin cost | 5-Iodotubercidin manufacturer | order 5-Iodotubercidin | 5-Iodotubercidin distributor